The central melanocortin system and human obesity
نویسندگان
چکیده
منابع مشابه
The central melanocortin system and the regulation of energy balance.
The central melanocortin system is comprised of discrete populations of neurons and circuits that play a key role in maintaining energy balance. This system can sense levels of peripheral energy stores and can integrate a variety of nutrient, neuronal and hormonal signals to regulate food intake, energy expenditure and nutrient metabolism. Disruption of this system at multiple levels causes obe...
متن کاملThe brain melanocortin system, sympathetic control, and obesity hypertension.
Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential...
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Individuals affected with either acute or chronic diseases often show disorders of nutrient balance. In some cases, a devastating state of malnutrition known as cachexia arises, brought about by a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. Stimulation of the hypothalamic melanocortin 4 receptor (MC4-R) produces relative an...
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Disruptions of the melanocortin signaling system have been linked to obesity. We investigated a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of adiposity through effects on nutrient partitioning and cellular lipid metabolism independent of nutrient intake. We report that pharmacological inhibition of melanocortin receptors (Mcr) in rats and genetic disruptio...
متن کاملCentral Obesity and Normochromic, Normocytic Anemia
Abstract Objective: Obesity is related to anemia which is explained its mechanism as disorder in iron absorption but the more rational reason is anemia of inflammation or anemia of chronic disease. The aim of this study was to define the prevalence of obesity in patients with normochromic normocytic anemia. Materials and methods: We screened 406 patients who were referred to endocrine cli...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2020
ISSN: 1759-4685
DOI: 10.1093/jmcb/mjaa048